Escalation with Overdose Control using All Toxicities and Time to Event Toxicity Data in Cancer Phase I Clinical Trials

The primary purposes of Phase I cancer clinical trials are to determine the maximum tolerated dose (MTD) and the treatment schedule of a new drug. Phase I trials usually involve a small number of patients so that fully utilizing all toxicity information including time to event toxicity data is key t...

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Detalhes bibliográficos
Main Authors: Chen, Zhengjia, Cui, Ye, Owonikoko, Taofeek K, Wang, Zhibo, Li, Zheng, Luo, Ruiyan, Kutner, Michael, Khuri, Fadlo R, Kowalski, Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046505/
https://ncbi.nlm.nih.gov/pubmed/24530487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2014.02.004
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