Adaptive Estimation of Personalized Maximum Tolerated Dose in Cancer Phase I Clinical Trials Based on All Toxicities and Individual Genomic Profile

BACKGROUND: Many biomarkers have been shown to be associated with the efficacy of cancer therapy. Estimation of personalized maximum tolerated doses (pMTDs) is a critical step toward personalized medicine, which aims to maximize the therapeutic effect of a treatment for individual patients. In this...

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Udgivet i:PLoS One
Main Authors: Chen, Zhengjia, Li, Zheng, Zhuang, Run, Yuan, Ying, Kutner, Michael, Owonikoko, Taofeek, Curran, Walter J., Kowalski, Jeanne
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268707/
https://ncbi.nlm.nih.gov/pubmed/28125617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170187
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