The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

Lysine acetylations are reversible posttranslational modifications of histone and non-histone proteins that play important regulatory roles in signal transduction cascades and gene expression. Lysine acetylations are regulated by histone acetyltransferases as writers and histone deacetylases as eras...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: van den Bosch, Thea, Boichenko, Alexander, Leus, Niek G. J., Eleni Ourailidou, Maria, Wapenaar, Hannah, Rotili, Dante, Mai, Antonello, Imhof, Axel, Bischoff, Rainer, Haisma, Hidde J., Dekker, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871277/
https://ncbi.nlm.nih.gov/pubmed/26718586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.12.010
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