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Mutations, kataegis, and translocations in B lymphocytes: towards a mechanistic understanding of AID promiscuous activity

As B cells engage in the immune response they express the deaminase AID to initiate the hypermutation and recombination of immunoglobulin genes, which are crucial processes for the efficient recognition and disposal of pathogens, However, AID must be tightly controlled in B cells to minimize off-tar...

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Dades bibliogràfiques
Publicat a:Nat Rev Immunol
Autors principals: Casellas, Rafael, Basu, Uttiya, Yewdell, William T., Chaudhuri, Jayanta, Robbiani, Davide F., Di Noia, Javier M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871114/
https://ncbi.nlm.nih.gov/pubmed/26898111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nri.2016.2
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