The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

Hexanucleotide repeat expansion in the C9orf72 gene is a leading cause of frontotemporal lobar degeneration (FTLD) with amyotrophic lateral sclerosis (ALS). Reduced expression of C9orf72 has been proposed as a possible disease mechanism. However, the cellular function of C9orf72 remains to be charac...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Sullivan, Peter M., Zhou, Xiaolai, Robins, Adam M., Paushter, Daniel H., Kim, Dongsung, Smolka, Marcus B., Hu, Fenghua
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870812/
https://ncbi.nlm.nih.gov/pubmed/27193190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0324-5
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