High Resolution Longitudinal Study of HIV-1 Env Vaccine-elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence

Due to the genetic variability of the HIV-1 envelope glycoproteins (Env), the elicitation of neutralizing antibodies to conserved neutralization determinants including the primary receptor binding site, CD4 binding site (CD4bs), is a major focus of vaccine development. To gain insight into the evolu...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Wang, Yimeng, Sundling, Christopher, Wilson, Richard, O’Dell, Sijy, Chen, Yajing, Dai, Kaifan, Phad, Ganesh E., Zhu, Jiang, Xiao, Yongli, Mascola, John R., Karlsson Hedestam, Gunilla B., Wyatt, Richard T., Li, Yuxing
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868635/
https://ncbi.nlm.nih.gov/pubmed/27001953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502543
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