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High Resolution Longitudinal Study of HIV-1 Env Vaccine-elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence

Due to the genetic variability of the HIV-1 envelope glycoproteins (Env), the elicitation of neutralizing antibodies to conserved neutralization determinants including the primary receptor binding site, CD4 binding site (CD4bs), is a major focus of vaccine development. To gain insight into the evolu...

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Αποθηκεύτηκε σε:

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:	J Immunol
Κύριοι συγγραφείς:	Wang, Yimeng, Sundling, Christopher, Wilson, Richard, O’Dell, Sijy, Chen, Yajing, Dai, Kaifan, Phad, Ganesh E., Zhu, Jiang, Xiao, Yongli, Mascola, John R., Karlsson Hedestam, Gunilla B., Wyatt, Richard T., Li, Yuxing
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2016
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4868635/ https://ncbi.nlm.nih.gov/pubmed/27001953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502543
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High Resolution Longitudinal Study of HIV-1 Env Vaccine-elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence

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