HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

The elicitation of HIV-1 broadly neutralizing antibodies following envelope glycoprotein (Env) vaccination is exceedingly difficult. Suboptimal engagement of naïve B cells is suggested to limit these low frequency events, especially at the conserved CD4bs. Here, we analyzed CD4bs-directed monoclonal...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dai, Kaifan, Khan, Salar N, Wang, Yimeng, He, Linling, Guenaga, Javier, Ingale, Jidnyasa, Sundling, Christopher, O’Dell, Sijy, McKee, Krisha, Phad, Ganesh, Corcoran, Martin, Wilson, Richard, Mascola, John R, Zhu, Jiang, Li, Yuxing, Hedestam, Gunilla B Karlsson, Wyatt, Richard T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754655/
https://ncbi.nlm.nih.gov/pubmed/26879974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20987
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