HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

The elicitation of HIV-1 broadly neutralizing antibodies following envelope glycoprotein (Env) vaccination is exceedingly difficult. Suboptimal engagement of naïve B cells is suggested to limit these low frequency events, especially at the conserved CD4bs. Here, we analyzed CD4bs-directed monoclonal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Dai, Kaifan, Khan, Salar N, Wang, Yimeng, He, Linling, Guenaga, Javier, Ingale, Jidnyasa, Sundling, Christopher, O’Dell, Sijy, McKee, Krisha, Phad, Ganesh, Corcoran, Martin, Wilson, Richard, Mascola, John R, Zhu, Jiang, Li, Yuxing, Hedestam, Gunilla B Karlsson, Wyatt, Richard T
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754655/
https://ncbi.nlm.nih.gov/pubmed/26879974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20987
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