HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

The elicitation of HIV-1 broadly neutralizing antibodies following envelope glycoprotein (Env) vaccination is exceedingly difficult. Suboptimal engagement of naïve B cells is suggested to limit these low frequency events, especially at the conserved CD4bs. Here, we analyzed CD4bs-directed monoclonal...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Rep
Κύριοι συγγραφείς: Dai, Kaifan, Khan, Salar N, Wang, Yimeng, He, Linling, Guenaga, Javier, Ingale, Jidnyasa, Sundling, Christopher, O’Dell, Sijy, McKee, Krisha, Phad, Ganesh, Corcoran, Martin, Wilson, Richard, Mascola, John R, Zhu, Jiang, Li, Yuxing, Hedestam, Gunilla B Karlsson, Wyatt, Richard T
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754655/
https://ncbi.nlm.nih.gov/pubmed/26879974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20987
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