HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

The elicitation of HIV-1 broadly neutralizing antibodies following envelope glycoprotein (Env) vaccination is exceedingly difficult. Suboptimal engagement of naïve B cells is suggested to limit these low frequency events, especially at the conserved CD4bs. Here, we analyzed CD4bs-directed monoclonal...

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Udgivet i:Sci Rep
Main Authors: Dai, Kaifan, Khan, Salar N, Wang, Yimeng, He, Linling, Guenaga, Javier, Ingale, Jidnyasa, Sundling, Christopher, O’Dell, Sijy, McKee, Krisha, Phad, Ganesh, Corcoran, Martin, Wilson, Richard, Mascola, John R, Zhu, Jiang, Li, Yuxing, Hedestam, Gunilla B Karlsson, Wyatt, Richard T
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754655/
https://ncbi.nlm.nih.gov/pubmed/26879974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20987
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