Characterizing genomic alterations in cancer by complementary functional associations

Systematic efforts to sequence the cancer genome have identified large numbers of relevant mutations and copy number alterations in human cancers; however, elucidating their functional consequences, and their interactions to drive or maintain oncogenic states, is still a significant challenge. Here...

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Veröffentlicht in:Nat Biotechnol
Hauptverfasser: Kim, J. W., Botvinnik, O. B., Abudayyeh, O., Birger, C., Rosenbluh, J., Shrestha, Y., Abazeed, M. E., Hammerman, P. S., DiCara, D., Konieczkowski, D. J., Johannessen, C. M., Liberzon, A., Alizad-Rahvar, A. R., Alexe, G., Aguirre, A., Ghandi, M., Greulich, H., Vazquez, F., Weir, B. A., Van Allen, E. M., Tsherniak, A., Shao, D. D., Zack, T. I., Noble, M., Getz, G., Beroukhim, R., Garraway, L. A., Ardakani, M., Romualdi, C., Sales, G., Barbie, D. A., Boehm, J. S., Hahn, W. C., Mesirov, J. P., Tamayo, P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868596/
https://ncbi.nlm.nih.gov/pubmed/27088724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3527
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