Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States

The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here, we describe Onco-GPS (OncoGenic...

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Published in:Cell Syst
Main Authors: Kim, Jong Wook, Abudayyeh, Omar O., Yeerna, Huwate, Yeang, Chen-Hsiang, Stewart, Michelle, Jenkins, Russell W., Kitajima, Shunsuke, Konieczkowski, David J., Medetgul-Ernar, Kate, Cavazos, Taylor, Mah, Clarence, Ting, Stephanie, Van Allen, Eliezer M., Cohen, Ofir, Mcdermott, John, Damato, Emily, Aguirre, Andrew J., Liang, Jonathan, Liberzon, Arthur, Alexe, Gabriella, Doench, John, Ghandi, Mahmoud, Vazquez, Francisca, Weir, Barbara A., Tsherniak, Aviad, Subramanian, Aravind, Meneses-Cime, Karina, Park, Jason, Clemons, Paul, Garraway, Levi A., Thomas, David, Boehm, Jesse S., Barbie, David A., Hahn, William C., Mesirov, Jill P., Tamayo, Pablo
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639711/
https://ncbi.nlm.nih.gov/pubmed/28837809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.08.002
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