Real-time single-molecule electronic DNA sequencing by synthesis using polymer-tagged nucleotides on a nanopore array

DNA sequencing by synthesis (SBS) offers a robust platform to decipher nucleic acid sequences. Recently, we reported a single-molecule nanopore-based SBS strategy that accurately distinguishes four bases by electronically detecting and differentiating four different polymer tags attached to the 5′-p...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Fuller, Carl W., Kumar, Shiv, Porel, Mintu, Chien, Minchen, Bibillo, Arek, Stranges, P. Benjamin, Dorwart, Michael, Tao, Chuanjuan, Li, Zengmin, Guo, Wenjing, Shi, Shundi, Korenblum, Daniel, Trans, Andrew, Aguirre, Anne, Liu, Edward, Harada, Eric T., Pollard, James, Bhat, Ashwini, Cech, Cynthia, Yang, Alexander, Arnold, Cleoma, Palla, Mirkó, Hovis, Jennifer, Chen, Roger, Morozova, Irina, Kalachikov, Sergey, Russo, James J., Kasianowicz, John J., Davis, Randy, Roever, Stefan, Church, George M., Ju, Jingyue
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2016
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868432/
https://ncbi.nlm.nih.gov/pubmed/27091962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601782113
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