Design and characterization of a nanopore-coupled polymerase for single-molecule DNA sequencing by synthesis on an electrode array

Scalable, high-throughput DNA sequencing is a prerequisite for precision medicine and biomedical research. Recently, we presented a nanopore-based sequencing-by-synthesis (Nanopore-SBS) approach, which used a set of nucleotides with polymer tags that allow discrimination of the nucleotides in a biol...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Stranges, P. Benjamin, Palla, Mirkó, Kalachikov, Sergey, Nivala, Jeff, Dorwart, Michael, Trans, Andrew, Kumar, Shiv, Porel, Mintu, Chien, Minchen, Tao, Chuanjuan, Morozova, Irina, Li, Zengmin, Shi, Shundi, Aberra, Aman, Arnold, Cleoma, Yang, Alexander, Aguirre, Anne, Harada, Eric T., Korenblum, Daniel, Pollard, James, Bhat, Ashwini, Gremyachinskiy, Dmitriy, Bibillo, Arek, Chen, Roger, Davis, Randy, Russo, James J., Fuller, Carl W., Roever, Stefan, Ju, Jingyue, Church, George M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098637/
https://ncbi.nlm.nih.gov/pubmed/27729524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608271113
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