Importin 8 mediates m(7)G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

Regulation of nuclear-cytoplasmic trafficking of oncoproteins is critical for growth homeostasis. Dysregulated trafficking contributes to malignancy, whereas understanding the process can reveal unique therapeutic opportunities. Here, we focus on eukaryotic translation initiation factor 4E (eIF4E),...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Volpon, Laurent, Culjkovic-Kraljacic, Biljana, Osborne, Michael J., Ramteke, Anup, Sun, Qingxiang, Niesman, Ashley, Chook, Yuh Min, Borden, Katherine L. B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868427/
https://ncbi.nlm.nih.gov/pubmed/27114554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524291113
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