Importin 8 mediates m(7)G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E

Regulation of nuclear-cytoplasmic trafficking of oncoproteins is critical for growth homeostasis. Dysregulated trafficking contributes to malignancy, whereas understanding the process can reveal unique therapeutic opportunities. Here, we focus on eukaryotic translation initiation factor 4E (eIF4E),...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Volpon, Laurent, Culjkovic-Kraljacic, Biljana, Osborne, Michael J., Ramteke, Anup, Sun, Qingxiang, Niesman, Ashley, Chook, Yuh Min, Borden, Katherine L. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868427/
https://ncbi.nlm.nih.gov/pubmed/27114554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524291113
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