Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation

Viruses have transformed our understanding of mammalian RNA processing, including facilitating the discovery of the methyl-7-guanosine (m(7)G) cap on the 5′ end of RNAs. The m(7)G cap is required for RNAs to bind the eukaryotic translation initiation factor eIF4E and associate with the translation m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Coutinho de Oliveira, Luciana, Volpon, Laurent, Rahardjo, Amanda K., Osborne, Michael J., Culjkovic-Kraljacic, Biljana, Trahan, Christian, Oeffinger, Marlene, Kwok, Benjamin H., Borden, Katherine L. B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6883836/
https://ncbi.nlm.nih.gov/pubmed/31712417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904752116
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