Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties

[Image: see text] The orally bioavailable 1-deoxy-sphingosine analog, Enigmol, has demonstrated anticancer activity in numerous in vivo settings. However, as no Enigmol analog with enhanced potency in vitro has been identified, a new strategy to improve efficacy in vivo by increasing tumor uptake wa...

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Publicat a:ACS Med Chem Lett
Autors principals: Miller, Eric J., Mays, Suzanne G., Baillie, Mark T., Howard, Randy B., Culver, Deborah G., Saindane, Manohar, Pruett, Sarah T., Holt, Jason J., Menaldino, David S., Evers, Taylor J., Reddy, G. Prabhakar, Arrendale, Richard F., Natchus, Michael G., Petros, John A., Liotta, Dennis C.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867483/
https://ncbi.nlm.nih.gov/pubmed/27190606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00113
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