Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties

[Image: see text] The orally bioavailable 1-deoxy-sphingosine analog, Enigmol, has demonstrated anticancer activity in numerous in vivo settings. However, as no Enigmol analog with enhanced potency in vitro has been identified, a new strategy to improve efficacy in vivo by increasing tumor uptake wa...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Miller, Eric J., Mays, Suzanne G., Baillie, Mark T., Howard, Randy B., Culver, Deborah G., Saindane, Manohar, Pruett, Sarah T., Holt, Jason J., Menaldino, David S., Evers, Taylor J., Reddy, G. Prabhakar, Arrendale, Richard F., Natchus, Michael G., Petros, John A., Liotta, Dennis C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2016
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867483/
https://ncbi.nlm.nih.gov/pubmed/27190606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00113
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