Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons

Although chemotherapy-induced peripheral neuropathy (CIPN) affects approximately 5-60% of cancer patients, there are currently no treatments available in part due to the fact that the underlying causes of CIPN are not well understood. One contributing factor in CIPN may be persistence of DNA lesions...

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Publicat a:DNA Repair (Amst)
Autors principals: Georgiadis, Millie M., Chen, Qiujia, Meng, Jingwei, Guo, Chunlu, Wireman, Randall, Reed, April, Vasko, Michael R., Kelley, Mark R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867230/
https://ncbi.nlm.nih.gov/pubmed/27078577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.03.009
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