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Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or–oxidizing agents, and has recently been identified as an important therapeutic target. In this work,...
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| Veröffentlicht in: | J Med Chem |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6583781/ https://ncbi.nlm.nih.gov/pubmed/30653918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01529 |
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