Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or–oxidizing agents, and has recently been identified as an important therapeutic target. In this work,...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Trilles, Richard, Beglov, Dmitri, Chen, Qiujia, He, Hongzhen, Wireman, Randall, Reed, April, Chennamadhavuni, Spandan, Panek, James S., Brown, Lauren E., Vajda, Sandor, Porco, John A., Kelley, Mark R., Georgiadis, Millie M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6583781/
https://ncbi.nlm.nih.gov/pubmed/30653918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01529
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