Characterization of the redox activity and disulfide bond formation in Apurinic/apyrimidinic endonuclease

Apurinic/apyrmidinic endonuclease (APE1) is an unusual nuclear redox factor in which the redox-active cysteines identified to date, C65 and C93, are surface inaccessible residues whose activities may be influenced by partial unfolding of APE1. To assess the role of the remaining five cysteines in AP...

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Bibliographic Details
Main Authors: Luo, Meihua, Zhang, Jun, He, Hongzhen, Su, Dian, Chen, Qiujia, Gross, Michael L., Kelley, Mark R., Georgiadis, Millie M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293223/
https://ncbi.nlm.nih.gov/pubmed/22148505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201034z
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