ETHANOL INHIBITS METHIONINE ADENOSYLTRANSFERASE II (MAT II) ACTIVITY AND S-ADENOSYLMETHIONINE (SAMe) BIOSYNTHESIS AND ENHANCES CASPASE-3 DEPENDENT CELL DEATH IN T LYMHOCYTES: RELEVANCE TO ALCOHOL INDUCED IMMUNOSUPPRESSION

An important aspect in alcohol abuse associated immune suppression is the loss of T helper CD4(+) lymphocytes leading to an impairment of multiple immune functions. Our work has shown that ethanol can sensitize CD4(+) T lymphocytes to activation-induced, caspase-3 dependent cell death (AICD). It has...

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Udgivet i:J Nutr Biochem
Main Authors: Hote, Prachi T., Sahoo, Rashmita, Jani, Tanvi S., Ghare, Smita S., Chen, Theresa, Joshi-Barve, Swati, McClain, Craig J., Barve, Shirish S.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867115/
https://ncbi.nlm.nih.gov/pubmed/17869084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2007.05.010
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