Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice

BACKGROUND & AIMS: Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality, with no Food and Drug Administration–approved therapy. Chronic alcohol consumption causes a pro-oxidant environment and increases hepatic lipid peroxidation, with acrolein being the most reactive/t...

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Publicado en:Cell Mol Gastroenterol Hepatol
Autores principales: Chen, Wei-Yang, Zhang, Jingwen, Ghare, Smita, Barve, Shirish, McClain, Craig, Joshi-Barve, Swati
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042858/
https://ncbi.nlm.nih.gov/pubmed/28119953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2016.05.010
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