Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice

BACKGROUND & AIMS: Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality, with no Food and Drug Administration–approved therapy. Chronic alcohol consumption causes a pro-oxidant environment and increases hepatic lipid peroxidation, with acrolein being the most reactive/t...

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發表在:Cell Mol Gastroenterol Hepatol
Main Authors: Chen, Wei-Yang, Zhang, Jingwen, Ghare, Smita, Barve, Shirish, McClain, Craig, Joshi-Barve, Swati
格式: Artigo
語言:Inglês
出版: Elsevier 2016
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042858/
https://ncbi.nlm.nih.gov/pubmed/28119953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2016.05.010
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