Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia

Leukemias bearing mixed lineage leukemia (MLL) rearrangement (MLL-R) resulting in expression of oncogenic MLL fusion proteins (MLL-FPs) represent an especially aggressive disease subtype with the worst overall prognoses and chemotherapeutic response. MLL-R leukemias are uniquely dependent on the epi...

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Bibliographic Details
Published in:Cells
Main Authors: Barve, Aditya, Vega, Alexis, Shah, Parag P., Ghare, Smita, Casson, Lavona, Wunderlich, Mark, Siskind, Leah J., Beverly, Levi J.
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912509/
https://ncbi.nlm.nih.gov/pubmed/31717699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8111322
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