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Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding

Transforming growth factor-β (TGF-β) family ligands are pleiotropic cytokines. Their physiological activities are not determined by a simple coupling of stimulus and response, but depend critically on context, i.e. the interplay of receptors, ligands, and regulators that form the TGF-β signal transd...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Aykul, Senem, Martinez-Hackert, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865925/
https://ncbi.nlm.nih.gov/pubmed/26961869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.713487
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