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Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα

Two metabolites from the ascomycete fungus Septofusidium berolinense were recently identified as having antineoplastic activity [Ekiz, et al. (2015) J. Antibiot. (Tokyo)]. However, the basis for this activity is not known. One of the compounds [3,6-dihydroxy-2-propylbenzaldehyde (GE-1)] is a hydroqu...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Vann, Kendra R., Ekiz, Güner, Zencir, Sevil, Bedir, Erdal, Topcu, Zeki, Osheroff, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864862/
https://ncbi.nlm.nih.gov/pubmed/26894873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00009
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