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Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα

Two metabolites from the ascomycete fungus Septofusidium berolinense were recently identified as having antineoplastic activity [Ekiz, et al. (2015) J. Antibiot. (Tokyo)]. However, the basis for this activity is not known. One of the compounds [3,6-dihydroxy-2-propylbenzaldehyde (GE-1)] is a hydroqu...

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Dettagli Bibliografici
Pubblicato in:Chem Res Toxicol
Autori principali: Vann, Kendra R., Ekiz, Güner, Zencir, Sevil, Bedir, Erdal, Topcu, Zeki, Osheroff, Neil
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864862/
https://ncbi.nlm.nih.gov/pubmed/26894873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00009
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