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Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
The tumor suppressor folliculin (FLCN) forms a repressor complex with AMP-activated protein kinase (AMPK). Given that AMPK is a master regulator of cellular energy homeostasis, we generated an adipose-specific Flcn (Adipoq-FLCN) knockout mouse model to investigate the role of FLCN in energy metaboli...
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| Yayımlandı: | Genes Dev |
|---|---|
| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4863735/ https://ncbi.nlm.nih.gov/pubmed/27151976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.281410.116 |
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