Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα

The tumor suppressor folliculin (FLCN) forms a repressor complex with AMP-activated protein kinase (AMPK). Given that AMPK is a master regulator of cellular energy homeostasis, we generated an adipose-specific Flcn (Adipoq-FLCN) knockout mouse model to investigate the role of FLCN in energy metaboli...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genes Dev
Egile Nagusiak: Yan, Ming, Audet-Walsh, Étienne, Manteghi, Sanaz, Dufour, Catherine Rosa, Walker, Benjamin, Baba, Masaya, St-Pierre, Julie, Giguère, Vincent, Pause, Arnim
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863735/
https://ncbi.nlm.nih.gov/pubmed/27151976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.281410.116
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