FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores

Mechanisms of adaptation to environmental changes in osmolarity are fundamental for cellular and organismal survival. Here we identify a novel osmotic stress resistance pathway in Caenorhabditis elegans (C. elegans), which is dependent on the metabolic master regulator 5’-AMP-activated protein kinas...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Possik, Elite, Ajisebutu, Andrew, Manteghi, Sanaz, Gingras, Marie-Claude, Vijayaraghavan, Tarika, Flamand, Mathieu, Coull, Barry, Schmeisser, Kathrin, Duchaine, Thomas, van Steensel, Maurice, Hall, David H., Pause, Arnim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595296/
https://ncbi.nlm.nih.gov/pubmed/26439621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005520
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