The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance

TFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. elegans and mammalian models, we report that the master metabolic modulator 5’-AMP-activated protein kinase (AMPK) and it...

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Udgivet i:Cell Rep
Main Authors: El-Houjeiri, Leeanna, Possik, Elite, Vijayaraghavan, Tarika, Paquette, Mathieu, Martina, José A, Kazan, Jalal M., Ma, Eric H., Jones, Russell, Blanchette, Paola, Puertollano, Rosa, Pause, Arnim
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457953/
https://ncbi.nlm.nih.gov/pubmed/30917316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.102
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