Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

DNA methylation is implicated in the acquisition of malignant phenotypes, and the use of epigenetic modulating drugs is a promising anti-cancer therapeutic strategy. 5-aza-2’deoxycytidine (decitabine, 5-azadC) is an FDA-approved DNA methyltransferase (DNMT) inhibitor with proven effectiveness agains...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Vernier, Mathieu, McGuirk, Shawn, Dufour, Catherine R., Wan, Liangxinyi, Audet-Walsh, Etienne, St-Pierre, Julie, Giguère, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544553/
https://ncbi.nlm.nih.gov/pubmed/32855526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01438-1
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