Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4

DNA methylation is implicated in the acquisition of malignant phenotypes, and the use of epigenetic modulating drugs is a promising anti-cancer therapeutic strategy. 5-aza-2’deoxycytidine (decitabine, 5-azadC) is an FDA-approved DNA methyltransferase (DNMT) inhibitor with proven effectiveness agains...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Vernier, Mathieu, McGuirk, Shawn, Dufour, Catherine R., Wan, Liangxinyi, Audet-Walsh, Etienne, St-Pierre, Julie, Giguère, Vincent
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544553/
https://ncbi.nlm.nih.gov/pubmed/32855526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01438-1
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