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Single Dose, CYP2D6 Genotype-Stratified Pharmacokinetic Study of Atomoxetine in Children with ADHD

The effect of CYP2D6 genotype on the dose-exposure relationship for atomoxetine has not been well characterized in children. Children 6–17 years of age diagnosed with ADHD were stratified by CYP2D6 genotype into groups with 0 (PM, n=4), 0.5 (IM, n=3), one (EM1, n=8) or two (EM2, n=8) functional alle...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Brown, Jacob T., Abdel-Rahman, Susan M., van Haandel, Leon, Gaedigk, Andrea, Lin, Yvonne S., Leeder, J. Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862932/
https://ncbi.nlm.nih.gov/pubmed/26660002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.319
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