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Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children
Atomoxetine (ATX) is a second-line nonstimulant medication used to control symptoms of attention deficit hyperactivity disorder (ADHD). Inconsistent therapeutic efficacy has been reported with ATX, which may be related to variable CYP2D6-mediated drug clearance. We characterized ATX metabolism in a...
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| Publicado no: | Drug Metab Dispos |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4931890/ https://ncbi.nlm.nih.gov/pubmed/27052878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.069518 |
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