Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children

Atomoxetine (ATX) is a second-line nonstimulant medication used to control symptoms of attention deficit hyperactivity disorder (ADHD). Inconsistent therapeutic efficacy has been reported with ATX, which may be related to variable CYP2D6-mediated drug clearance. We characterized ATX metabolism in a...

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Bibliografiske detaljer
Udgivet i:Drug Metab Dispos
Main Authors: Dinh, Jean C., Pearce, Robin E., Van Haandel, Leon, Gaedigk, Andrea, Leeder, J. Steven
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2016
Fag:
Special Section on Pediatric Drug Disposition and Pharmacokinetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931890/
https://ncbi.nlm.nih.gov/pubmed/27052878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.069518
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