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Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes
Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Cl...
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| 發表在: | Sci Rep |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6098032/ https://ncbi.nlm.nih.gov/pubmed/30120390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30841-8 |
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