Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes

Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Cl...

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Udgivet i:Sci Rep
Main Authors: Kim, Se-Hyung, Byeon, Ji-Young, Kim, Young-Hoon, Lee, Choong-Min, Lee, Yun Jeong, Jang, Choon-Gon, Lee, Seok-Yong
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098032/
https://ncbi.nlm.nih.gov/pubmed/30120390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30841-8
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