Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa

Development of spontaneous mutations in Pseudomonas aeruginosa has been associated with antibiotic failure, leading to high rates of morbidity and mortality. Our objective was to evaluate the pharmacodynamics of polymyxin B combinations against rapidly evolving P. aeruginosa mutator strains and to c...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Ly, Neang S., Bulman, Zackery P., Bulitta, Jürgen B., Baron, Christopher, Rao, Gauri G., Holden, Patricia N., Li, Jian, Sutton, Mark D., Tsuji, Brian T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862466/
https://ncbi.nlm.nih.gov/pubmed/26926641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02377-15
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