Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin

The impact of quorum sensing on polymyxin and azithromycin pharmacodynamics was assessed in Pseudomonas aeruginosa PAO1 and an isogenic rhlR/lasR double knockout. For polymyxin B, greater killing against the rhlR/lasR knockout than against PAO1 was observed at 10(8) CFU/ml (polymyxin B half-maximal...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Bulman, Zackery P., Ly, Neang S., Lenhard, Justin R., Holden, Patricia N., Bulitta, Jürgen B., Tsuji, Brian T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365695/
https://ncbi.nlm.nih.gov/pubmed/28096154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00096-16
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items