Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

OBJECTIVES: Polymyxin B is being increasingly utilized as a last resort against resistant Gram-negative bacteria. We examined the pharmacodynamics of novel dosing strategies for polymyxin B combinations to maximize efficacy and minimize the emergence of resistance and drug exposure against Acinetoba...

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Detalles Bibliográficos
Publicado en:J Antimicrob Chemother
Main Authors: Rao, Gauri G., Ly, Neang S., Bulitta, Jürgen B., Soon, Rachel L., San Roman, Marie D., Holden, Patricia N., Landersdorfer, Cornelia B., Nation, Roger L., Li, Jian, Forrest, Alan, Tsuji, Brian T.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079300/
https://ncbi.nlm.nih.gov/pubmed/27494922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw293
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