Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

OBJECTIVES: Polymyxin B is being increasingly utilized as a last resort against resistant Gram-negative bacteria. We examined the pharmacodynamics of novel dosing strategies for polymyxin B combinations to maximize efficacy and minimize the emergence of resistance and drug exposure against Acinetoba...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Rao, Gauri G., Ly, Neang S., Bulitta, Jürgen B., Soon, Rachel L., San Roman, Marie D., Holden, Patricia N., Landersdorfer, Cornelia B., Nation, Roger L., Li, Jian, Forrest, Alan, Tsuji, Brian T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079300/
https://ncbi.nlm.nih.gov/pubmed/27494922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw293
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