From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity

Existing therapies for leishmaniases present significant limitations, such as toxic side effects, and are rendered inefficient by parasite resistance. It is of utmost importance to develop novel drugs targeting Leishmania that take these two limitations into consideration. We thus chose a target-bas...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Durieu, Emilie, Prina, Eric, Leclercq, Olivier, Oumata, Nassima, Gaboriaud-Kolar, Nicolas, Vougogiannopoulou, Konstantina, Aulner, Nathalie, Defontaine, Audrey, No, Joo Hwan, Ruchaud, Sandrine, Skaltsounis, Alexios-Leandros, Galons, Hervé, Späth, Gerald F., Meijer, Laurent, Rachidi, Najma
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862455/
https://ncbi.nlm.nih.gov/pubmed/26902771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00021-16
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