Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection

Protein kinase inhibitors have emerged as new drugs in various therapeutic areas, including leishmaniasis, an important parasitic disease. Members of the Leishmania casein kinase 1 (CK1) family represent promising therapeutic targets. Leishmania casein kinase 1 isoform 2 (CK1.2) has been identified...

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Autors principals: Rachidi, Najma, Taly, Jean François, Durieu, Emilie, Leclercq, Olivier, Aulner, Nathalie, Prina, Eric, Pescher, Pascale, Notredame, Cedric, Meijer, Laurent, Späth, Gerald F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957854/
https://ncbi.nlm.nih.gov/pubmed/24366737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02022-13
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