Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection

Protein kinase inhibitors have emerged as new drugs in various therapeutic areas, including leishmaniasis, an important parasitic disease. Members of the Leishmania casein kinase 1 (CK1) family represent promising therapeutic targets. Leishmania casein kinase 1 isoform 2 (CK1.2) has been identified...

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Détails bibliographiques
Auteurs principaux: Rachidi, Najma, Taly, Jean François, Durieu, Emilie, Leclercq, Olivier, Aulner, Nathalie, Prina, Eric, Pescher, Pascale, Notredame, Cedric, Meijer, Laurent, Späth, Gerald F.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957854/
https://ncbi.nlm.nih.gov/pubmed/24366737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02022-13
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