PDL1 Regulation by p53 via miR-34

BACKGROUND: Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non–small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that PDL1 is regulated by p53 via miR-34. METHODS: p53 wild-type and p53-deficient cell lines (p53(–/...

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Pubblicato in:J Natl Cancer Inst
Autori principali: Cortez, Maria Angelica, Ivan, Cristina, Valdecanas, David, Wang, Xiaohong, Peltier, Heidi J., Ye, Yuping, Araujo, Luiz, Carbone, David P., Shilo, Konstantin, Giri, Dipak K, Kelnar, Kevin, Martin, Desiree, Komaki, Ritsuko, Gomez, Daniel R., Krishnan, Sunil, Calin, George A., Bader, Andreas G., Welsh, James W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862407/
https://ncbi.nlm.nih.gov/pubmed/26577528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv303
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