Ikaros Is a Negative Regulator of B1 Cell Development and Function

B1 B cells secrete most of the circulating natural antibodies and are considered key effector cells of the innate immune response. However, B1 cell-associated antibodies often cross-react with self-antigens, which leads to autoimmunity, and B1 cells have been implicated in cancer. How B1 cell activi...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Macias-Garcia, Alejandra, Heizmann, Beate, Sellars, MacLean, Marchal, Patricia, Dali, Hayet, Pasquali, Jean-Louis, Muller, Sylviane, Kastner, Philippe, Chan, Susan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861476/
https://ncbi.nlm.nih.gov/pubmed/26841869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704239
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