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Ikaros antagonizes DNA binding by STAT5 in pre-B cells
The IKZF1 gene, which encodes the Ikaros transcription factor, is frequently deleted or mutated in patients with B-cell precursor acute lymphoblastic leukemias that express oncogenes, like BCR-ABL, which activate the JAK-STAT5 pathway. Ikaros functionally antagonizes the transcriptional programs dow...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7660478/ https://ncbi.nlm.nih.gov/pubmed/33180866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242211 |
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