Ikaros antagonizes DNA binding by STAT5 in pre-B cells

The IKZF1 gene, which encodes the Ikaros transcription factor, is frequently deleted or mutated in patients with B-cell precursor acute lymphoblastic leukemias that express oncogenes, like BCR-ABL, which activate the JAK-STAT5 pathway. Ikaros functionally antagonizes the transcriptional programs dow...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Heizmann, Beate, Le Gras, Stéphanie, Simand, Célestine, Marchal, Patricia, Chan, Susan, Kastner, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660478/
https://ncbi.nlm.nih.gov/pubmed/33180866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242211
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