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Evidence That Does Not Support Pyruvate Kinase M2 (PKM2)-catalyzed Reaction as a Rate-limiting Step in Cancer Cell Glycolysis

It has been recognized that the rate-limiting function of pyruvate kinase M2 (PKM2) in glycolysis plays an important role in distributing glycolytic intermediates for anabolic and catabolic purposes in cancer cells. However, after analysis of the catalytic capacity of PKM2 relative to other glycolyt...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Xie, Jiansheng, Dai, Chunyan, Hu, Xun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861469/
https://ncbi.nlm.nih.gov/pubmed/26917721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704825
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