The Scaffold Protein KSR1, A Novel Therapeutic Target for the Treatment of Merlin-Deficient Tumors

Merlin has broad tumor suppressor functions as its mutations have been identified in multiple benign tumors and malignant cancers. In all schwannomas, the majority of meningiomas and 1/3 of ependymomas Merlin loss is causative. In Neurofibromatosis type 2, a dominantly inherited tumor disease due to...

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Veröffentlicht in:Oncogene
Hauptverfasser: Zhou, Lu, Lyons-Rimmer, Jade, Ammoun, Sylwia, Müller, Jürgen, Lasonder, Edwin, Sharma, Vikram, Ercolano, Emanuela, Hilton, David, Taiwo, Ifeoluwatola, Barczyk, Magdalena, Hanemann, C. Oliver
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861249/
https://ncbi.nlm.nih.gov/pubmed/26549023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.404
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