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The Potential of MLN3651 in Combination with Selumetinib as a Treatment for Merlin-Deficient Meningioma

Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex, CRL4-DCAF1, and the Raf/MEK/ERK scaffold protein Kinase s...

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Библиографические подробности
Опубликовано в: :Cancers (Basel)
Главные авторы: Lyons Rimmer, Jade, Ercolano, Emanuela, Baiz, Daniele, Makhija, Mahindra, Berger, Allison, Sells, Todd, Stroud, Steve, Hilton, David, Adams, Claire L., Hanemann, C Oliver
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407567/
https://ncbi.nlm.nih.gov/pubmed/32629964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12071744
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